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BiologyScience

Neanderthals and Denisovans divide

Nuclear DNA from the Pit of the Bones shows the two lineages had already parted by 430,000 years ago.

When
—
Duration
30 thousand years
Known to
± 30 thousand years
Era
Middle Pleistocene, Quaternary

Sequencing nuclear DNA from Sima de los Huesos — an extraordinary technical achievement, since DNA at that age is normally destroyed — showed the individuals were on the Neanderthal branch and not the Denisovan one. That single result dates the Neanderthal-Denisovan divergence to before 430,000 years ago, and it pushed the recoverable genetic record back roughly ten times further than had been thought possible. Ancient DNA stopped being a Late Pleistocene tool at that moment.

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